Coagulopathy, Liver Transplant Disorder
Conditions
Brief summary
Thromboelastometry better assess coagulation than standard coagulation test in patients undergoing ortothopic liver transplantation. In a post-hoc analysis from a randomized study recently conducted by our group, presurgical values of MA10 Extem \< 35 mm are highly predictive of RBC administration , with no further improvement over MA10 Extem \>40 mm ; suggesting that MA10 Extem between 35-40 would be the optimal range to manage blood product administration. The aim of the study is to validate this result in a prospective cohort of patients submitted to ortothopic liver transplantation.
Interventions
OTHERFibrinogen and/or platelets administration
Fibrinogen and/or platelets administration to maintain clot amplitude at 10 minutes of the thromboelastometry between 35-40 mm along liver transplant procedure
Sponsors
Hospital Clinic of Barcelona
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Presurgical hemoglobin \< 13 d/L and clot firmness at 10 minutes Extem \< 35 mm
Exclusion criteria
* Previous thrombosis * Antithrombotic treatment * No consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Red blood cell transfusion | until 24h after liver transplant |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Thrombosis | 28 days after liver transplant | Thrombosis will be assessed clinically and confirmed by ultrasonographic exam |
Countries
Spain
Contacts
Primary ContactAnnabel Blasi, MD, PhD
Outcome results
None listed