Oral Lichen Planus Related Stress
Conditions
Brief summary
Oral lichen planus (OLP) is a T-cell mediated chronic immunological disease directed to a still unknown antigen. It is a mucocutaneous and a psychosomatic disorder, with unknown prevalence rate; however studies suggest an incidence of 0.02 to 0.22% among the Indian population. 75% of patients with cutaneous lichen planus also experience oral lesions and may be precipitated or exacerbated by psychosocial stressors. In conditions like pain, anxiety and stress, many metabolic and endocrine changes occur in the body, the most common effect of which is increased cortisol level in blood. This hormone is a 21-carbon corticosteroid secreted by adrenal cortex and regulates the metabolism of carbohydrates, fats, proteins and water. Also known as stress hormone, cortisol is a decisive index in stressful situations. This study is intended to correlate the serum cortisol levels with anxiety and depression in patients with symptomatic oral lichen planus. This study attempts to evaluate psychological anxiety and depression in oral lichen planus subjects using Hospital Anxiety and Depression Scale ( HADS) and correlating with their serum cortisol levels. To understand and explore the etiopathogenesis for better management of oral lichen planus.
Detailed description
Oral lichen planus (OLP) is a T-cell mediated chronic immunological disease directed to a still unknown antigen. It is a mucocutaneous and a psychosomatic disorder, with unknown prevalence rate; however studies suggest an incidence of 0.02 to 0.22% among the Indian population. 75% of patients with cutaneous lichen planus also experience oral lesions and may be precipitated or exacerbated by psychosocial stressors. In conditions like pain, anxiety and stress, many metabolic and endocrine changes occur in the body, the most common effect of which is increased cortisol level in blood. This hormone is a 21-carbon corticosteroid secreted by adrenal cortex and regulates the metabolism of carbohydrates, fats, proteins and water. Also known as stress hormone, cortisol is a decisive index in stressful situations. This study is intended to correlate the serum cortisol levels with anxiety and depression in patients with symptomatic oral lichen planus.
Interventions
PROCEDUREvenepuncture
for both the groups, HADS questionnaire will be administered to assess the levels of anxiety and depression. The placebo group ( group A) will not be having subjects suffering from oral lichen planus
Sponsors
Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Clinical features with burning sensation on eating spicy food. * Patients with symptomatic Oral lichen planus evaluated clinically and histologically.
Exclusion criteria
* Patients not willing to be part of the study. * Patients who are on corticosteroid therapy. * Patients with endocrinal disorders which can alter adrenal gland function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum- cortisol levels from venous blood. | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| Hospital Anxiety and Depression scale | 1 year |
Countries
India
Outcome results
None listed