The Effect of Pasteurized; Pasteurized and Homogenized and UHT Treated Homogenized Cow's Milk on Gastrointestinal Symptoms in Sensitive Adults

The Effect of Pasteurized; Pasteurized and Homogenized and UHT -Treated Homogenized Cow's Milk on Gastrointestinal Symptoms in Sensitive Adults

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03010904

Enrollment

Registered

2017-01-05

Start date

2017-01-31

Completion date

2018-05-31

Last updated

2022-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Unidentified Gastrointestinal Discomfort Following Dairy Consumption

Brief summary

This study aims to investigate differences in digestion rates and gastrointestinal problems caused by pasteurized; pasturized and homogenized as well as UHT-treated homogenized cow's milks in healthy adults by diary of symptoms, blood glucose and triacylglycerol levels and plasma cytokine levels.

Interventions

OTHERDietary intervention

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Homogenized and pasteurized milk causes gastrointestinal problems (self-reported) unhomogenized and unpasteurized milk does not cause gastrointestinal problems (self-reported) * age 18-65 * BMI 18,5 - 30 * hemoglobin under normal range * fasting plasma alanine aminotransferase ALAT \< 60 U/l (normal liver function) * fasting plasma thyroid-stimulating hormone (TSH) 0.4 - 4.5 mU/l (normal thyroid function) * fasting plasma creatinine \< 118 umol/l (normal kidney function)

Exclusion criteria

* pace maker * Crohn's disease or other disease of the intestinal tract * intestinal operation within the last 3 months * difficult dysphagia * smoking * constipation * lactose intolerance * coeliac disease

Design outcomes

Primary

Measure	Time frame	Description
Gastrointestinal symptoms (self reported)	day 0 - day 5	Gastrointestinal symptoms (self-reported) as measured by a questionnaire. The questionnaire is devided into seven types of gastrointestinal discomfort, and also includes a possibility to describe a gastrointestinal discomfort outside these seven given alternatives. The severity of the symptoms is self-reported on a three-step scale.

Secondary

Measure	Time frame
Plasma triacylglycerols	20 min, 40 min, 60 min, 120 min, 180 min, 240 min, 300 min
Plasma glucose	20 min, 40 min, 60 min, 120 min, 180 min, 240 min, 300 min
Plasma insulin	20 min, 40 min, 60 min, 120 min, 180 min, 240 min, 300 min

Countries

Finland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026