Aneurysm, Dissecting, Aortic Aneurysm, Thoracic
Conditions
Brief summary
This is a national registry study to determine genetic risk factor and serial biomarkers of thoracic aortic aneurysm/dissection
Interventions
None listed
Sponsors
Beijing Institute of Heart, Lung and Blood Vessel Diseases
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Case Inclusion Criteria: 1. Subject who was diagnosed as thoracic aortic aneurysm/dissection by CT angiography, interventional angiography or vascular ultrasound; 2. Age is less than 80 years old; 3. male and non pregnancy female; 4. Subject understands study requirements aand agrees to sign an informed consent form prior to any study procedures. Case
Exclusion criteria
Subject has one of the following: 1. Pseudoaneurysm; 2. Previous infection or trauma in the damaged part of aorta; 3. Pregnancy female; 4. Participate in other clinical trials in the last 1 months. Control Inclusion Criteria: 1. Age and gender are matched with cases; 2. No aortic disease was detected by outpatient ultrasound; 3. No family history of cardiovascular disease; 4. Normal biochemical indicators; Criteria for culling, shedding and suspension testing: 1. Culling: Unqualified cases and controls. Data of culled subjects can not be used for statistical analysis; 2. Shedding: Subject that self withdrawal, loss to follow-up, or quitted by doctors; Reasons for shedding should be indicated for each shed subject. 3. Suspension: a) The researchers found significant safety problems or wrong study design; b) Researchers cannot continue clinical research due to funding or management reasons; c) Director ends the study. When suspension happens, all the CRF table should be reserved for future reference.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The location of Aneurysm/Dissection | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| Age for each participant | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| Gender for each participant | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| Height for each participant | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| Weight for each participant | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| Contact information for each participant | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| Past Medical History including disease history, surgical history, and family medical history | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| Lifestyle including smoking history and drinking, specify how many years smoking or drinking lasted and detail quantity per day | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| Exon sequencing data of each participant | Sequencing will be carried out in an average of 3 months after sample recruiting |
| Serum biomarker screening data of each participant | Screening will be carried out in an average of 3 months after sample recruiting |
| The size of Aneurysm/Dissection | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| blood biochemical index：blood lipid | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| blood biochemical index：blood glucose | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| blood biochemical index：uric acid | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| blood biochemical index：urea | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| blood biochemical index：creatinine | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| blood biochemical index：C reactive protein | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| blood biochemical index：d dime | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| Drug treatment | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| Surgery type | These data is collected from the cases' medical record in an average of 1 month after the sample recruiting |
| Prognosis information: all-cause death | These data is collected during follow-up visit at 3/6/12 months after discharge |
| Prognosis information: whether recidivation happened | These data is collected during follow-up visit at 3/6/12 months after discharge |
| Prognosis information including: whether other related disease happened | These data is collected during follow-up visit at 3/6/12 months after discharge |
Countries
China
Contacts
Primary ContactYulin Li, PHD
Outcome results
None listed