Latent Tuberculosis Infection in Korean Health Care Workers

Latent Tuberculosis Infection in Korean Health Care Workers Using Interferon Gamma Releasing Assay

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03010111

Enrollment

240

Registered

2017-01-04

Start date

2016-12-31

Completion date

2017-12-31

Last updated

2017-01-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Latent Tuberculosis

Keywords

Latent Tuberculosis, Interferons, Tuberculosis, Healthcare

Brief summary

The investigators aim to study the prevalence of latent tuberculosis infection (LTBI) using whole-blood interferon-r release assays, and determine the risk factors of LTBI in Korean health care workers.

Detailed description

Further study details as provided by Hanyang University Hospital

Interventions

OTHERQFT-IT Test and other blood sampling

In all enrolled health care workers, QFT-IT Test and other blood sampling were performed.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Health care workers in University affiliated hospital * Adult aged 20-65

Exclusion criteria

* Active tuberculosis * Subjects diagnosed with HIV infection, malignancy * Subjects having immunosuppressive drug therapy

Design outcomes

Primary

Measure	Time frame	Description
Percentage of latent tuberculosis infection developed in Korean health care workers	Three months	The participants performed QuaniFERON-TB Gold In-Tube test (QFT-IT test) and blood sampling at enrollment. So, the length of time which from the start of the first test of very first participants to the end of test of very last participant is 3 months. The percentage of participants with LTBI in health care workers was evaluated.

Secondary

Measure	Time frame	Description
Annual incidence of latent tuberculosis infection in Korean health care workers	1 year after first QFT-IT test (12-15 months)	QFT-IT test was performed at enrollment and repeated at point of one year after enrollment. So, the length of time which from the start of the first test of very first participants to the end of the second test of very last participant is 12 to 15 months. The percentage of participants with positive conversion in follow-up QFT-IT test (second test) was evaluated in participants who had negative results in the first QFT-IT test. Annual infection of LTBI was evaluated with the conversion of QFT-IT test through annual check up of QFT-IT test.

Countries

South Korea

Contacts

Primary ContactDong Won Park, M.D., Ph.D.

portrayme@hanmail.net

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026