Biochemical Mediators After Implant Loading

Nitric Oxide and Arginase Levels in Peri-Implant Tissues After Delayed Loading

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03009942

Enrollment

Registered

2017-01-04

Start date

2010-01-31

Completion date

2012-12-31

Last updated

2017-01-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Implant Loading

Keywords

nitric oxide, arginase, loading

Brief summary

This study evaluates the nitric oxide and arginase levels in patients with dental implants. Peri-implant sulcular fluid and saliva samples were collected after loading of the implants

Detailed description

Nitric oxide (NO) metabolism is associated with the clinical inflammatory state of peri-implant tissues and also affected by the mechanic stimulus. Therefore, The NO content of PISF reflects two different measures and can serve as an indicator of peri-implant soft tissue inflammation and/or bone response to force application and loading Arginase may reduce NO production by depleting the common substrate. Thus, increased salivary arginase activities detected in periodontitis patients may cause decreased NO synthesis and lead to a decrease in the antibacterial property of saliva.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients with ≥ 20 teeth, no systemic diseases that could affect bone metabolism, no smoking habits, and had one or more implants

Design outcomes

Primary

Measure	Time frame	Description
Biochemical parameters (nitric oxide and arginase) in periimplant sulcular fluid and saliva	Baseline and 1, 3 and 6 months after implant loading	The changes in nitric oxide and arginase levels after implant loading were determined.

Secondary

Measure	Time frame	Description
Plaque index	Baseline and 1, 3 and 6 months after implant loading	The changes in plaque index after implant loading. Plaque index was recorded for determining and classifying oral hygiene status.
Gingival index	Baseline and 1, 3 and 6 months after implant loading	The changes in gingival index after implant loading. Gingival index was recorded for classifying and evaluating gingival inflammation.
Probing depth	Baseline and 1, 3 and 6 months after implant loading	The changes in probing pocket depth after implant loading.Probing pocket depth was measured for determining periimplant health.
Bleeding on probing	Baseline and 1, 3 and 6 months after implant loading	The changes in bleeding on probing after implant loading. Bleeding on probing was recorded for evaluating gingival inflammation.

Outcome results