Infertility
Conditions
Brief summary
Polycystic ovary syndrome is the major cause of anovulatory infertility. Clomiphene citrate is the most commonly used oral agent for ovulation induction in this group, but there are some drawbacks with the use of it.
Interventions
DRUGLetrozole
oral tablets 2.5 mg
PROCEDUREovarian drilling
laparoscopic electrocauterization
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* History of at least one year of infertility either primary or secondary. * Body mass index: 25-35 * Normal fallopian tubes * Normal semen analysis of the husband * Women who will accept to participate in the study
Exclusion criteria
* Body mass index above 35 * Contraindication to general anesthesia * Previous laparoscopic drilling * Presence of other causes of infertility * Women who had received metformin, gonadotrophin, oral contraceptives or other hormonal drugs during the preceding 6 months * Women who intended to start a diet program * Women who will refuse to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ovulation rate | 3 months |
Secondary
| Measure | Time frame |
|---|---|
| The mid-cyclic endometrial thickness | one day |
Countries
Egypt
Contacts
Primary ContactAhmed Abbas, MD
Outcome results
None listed