Bowel Dysfunction, Rectal Cancer
Conditions
Keywords
rectal cancer, anterior resection syndrome, sphincter-preserving surgery
Brief summary
This research plans to collect rectal cancer patients after sphincter-preserving surgery from 14 institutions in China mainland, observe the incidence and risk factors about bowel dysfunction after operation.
Interventions
None listed
Sponsors
The First People's Hospital of Changzhou
Peking University Cancer Hospital & Institute
Beijing Friendship Hospital
Guangdong Provincial Hospital of Traditional Chinese Medicine
Hebei Medical University Fourth Hospital
First Affiliated Hospital of Jiamusi University
China-Japan Friendship Hospital
The First Hospital of Jilin University
The First Affiliated Hospital of Anhui Medical University
The Affiliated Hospital of the Chinese Academy of Military Medical Sciences
Xiangya Hospital of Central South University
Qilu Hospital of Shandong University (Qingdao)
Peking University International Hospital
Peking University People's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age ≥ 18 years 2. Adenocarcinoma confirmed by pathology 3. Distance from the lowest margin of tumor to the anal verge is ≤ 12cm, confirmed by hard sigmoidoscope. 4. The tumor is estimated to be resectable and confirmed by multidisciplinary team (MDT). 5. The operation is estimated to be sphincter-preserving. 6. The Eastern Cooperative Oncology Group(ECOG) performance status score of patient is ≤ 2. 7. The estimated life time is not less than one year. 8. The patient agree to sign the informed consent.
Exclusion criteria
1. The patient refuse to follow research plan. 2. Emergency case 3. Pregnant and lactating female patient 4. The patient did not accept radical resection. 5. The patient did not accept first stage resection and anastomosis. 6. The patient has experienced anal-rectal surgery. 7. The patient has experienced left colon surgery. 8. The patient suffered long-existing bowel dysfunction before rectal cancer diagnosis. 9. The patient was diagnosed with cognitive or communicative obstacles. 10. The patient was diagnosed with serious repeated infection or other concomitance diseases. 11. The patient has participated other medical research which may affect his/her bowel function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of bowel dysfunction after sphincter-preserving surgery | one year |
| Risk factors of bowel dysfunction after sphincter-preserving surgery | one year |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of each symptoms of bowel dysfunction | one year | — |
| Prognosis of bowel dysfunction after sphincter-preserving surgery | one year | — |
| Incidence of bowel dysfunction after sphincter-preserving surgery | one year | comparing incidences between high and low anastomsis site |
Contacts
Primary ContactFan Liu, M.D.
Outcome results
None listed