Leishmaniasis
Conditions
Brief summary
The investigators will compare the common treatment for cutaneous leishmaniasis with intra-lesional Pentostam to fractional CO2 laser with topical application of Pentostam. Outcome will be final scar appearance assesd by two dermatologist and pain measurement by VAS.
Detailed description
20 healthy patients diagnosed will cutaneous leishmaniasis with more than one lesion will be recruited. Half of the lesions will be treated with intra-lesional injections of Pentostam, and the other half by CO2 laser with topical application of Pentostam. Each lesion will recieve 3 treatments, one month apart between treatments. The patients will scale pain level of each treatment. Final scar appearance will be assessed by two dermatologists, without knowing what treatment was applied to each lesion.
Interventions
DRUGLocal application pentostam
DRUGintra-lisional pentostam
DEVICEfractional CO2 laser
Sponsors
Tel-Aviv Sourasky Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Objective cutaneous leishmaniasis diagnosis. * More than one Lesion
Exclusion criteria
* Previous treatment * Abnormal scarring
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| scar appearance | At sixth month | Each lesion will be photographed prior to treatment and at 6th month (Three months after last (3rd) treatment).Two dermatologist will asses each lesion outcome |
Secondary
| Measure | Time frame |
|---|---|
| Pain assessed by VAS | at one month, two months, and three months |
Outcome results
None listed