Myocardial Ischemia
Conditions
Brief summary
The overall aim of this study is to determine whether non-invasive imaging with myocardial contrast echocardiography using can provide information on the presence and spatial extent of recent myocardial ischemia by non-invasive echocardiographic imaging.
Interventions
DRUGSonazoid
Myocardial contrast echocardiography ischemic memory imaging using intravenous administration of Sonazoid
Sponsors
Oregon Health and Science University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
NORMAL CONTROL GROUP Inclusion Criteria: * Normal control individuals
Exclusion criteria
* History of cardiovascular disease (coronary artery disease, MI, peripheral artery disease) * allergy to eggs or ultrasound contrast agents * known or detected right to left shunt * presence of a wall motion abnormality * pregnancy ACS GROUP Inclusion Criteria: * Patients with diagnosis of acute coronary syndrome with either unstable angina or non-ST-elevation MI * Referred for primary percutaneous intervention * At least 1 high risk features (ST changes, positive troponin, wall motion abnormality)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dose optimization | 3 months | Dose ranging in normal controls to define highest dose of ultrasound contrast agent that does not produce delayed opacification from myocardial retention |
| Detection of Ischemia | 1 year | — |
Countries
United States
Contacts
Primary ContactJonathan R Lindner, MD
Outcome results
None listed