Preimplant Site Augmentation Using MPM Versus Autogenous Bone Graft

Implant Insertion in Defective Anterior Maxillary Ridge Augmented Using Mineralized Plasmatic Matrix Versus Autogenous Bone Graft

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03007069

Enrollment

Registered

2017-01-02

Start date

2017-01-31

Completion date

2017-12-31

Last updated

2017-01-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Resorption

Brief summary

Using growth factors obtained from patient's venous blood mixed with particulate autogenous bone the study compares bone gain by implant with gold standards.

Detailed description

To study the effectiveness of MPM in ridge augmentation with implant insertion compared with autogenous bone graft. -PICO- Population (P): Patients with defective maxillary alveolar ridge requiring implant insertion. Intervention (I): Ridge augmentation with MPM. Comparator (C): Autogenous bone graft. Outcome (O): Patient satisfaction - Implant stability.

Interventions

OTHERMineralized plasmatic matrix (MPM).

By using venoud blood from the patient, together with bone graft, a centrifuge will be used to obtain the top layer after centrifuging blood at 3000 RPM, for 10 minutes , Which will result if sticky bone graft consistency after mixing.

OTHERAutogenous bone graft (gold standard).

Exposed implant threads are to be covered with autogenous bone and collagen membrane.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

1. Medically free patients. 2. Evaluated bone height on CBCT to be (0-4 mm buccal bone dehiscence) and width (not less than 4.5 mm) 3. Patients with Anterior maxillary defective partially edentulous ridge. 4. Age between 18 and 40 years. 5. Both sexes. 6. Patients physically able to tolerate surgical and restorative procedures. 7. Patients with an opposing tooth to the pre-implant site. 8. Good oral hygiene. 9. Highly motivated patients.

Exclusion criteria

1. Patients allergic to local anesthetic agent. 2. Pregnant or lactating females. 3. Presence of any pathosis in the pre-implant site. 4. Presence of any mucosal disease. 5. Presence of parafunctional habits. 6. History of oral radiotherapy. 7. History of prolonged steroids use. 8. Psychological disorders.

Design outcomes

Primary

Measure	Time frame
Patient Satisfaction regarding esthetic results , outcome will be measure using questionnaire.	5 months

Secondary

Measure	Time frame
Stability of dental implants , this will be measured using Ostell device in ISQ units.	5 months.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026