Genetic Variation in Gonadotropin and Gonadotropin Receptor Genes and Suboptimal Response

Genetic Variation in Gonadotropin and Gonadotropin Receptor Genes as a Causative Factor of Suboptimal Response Following Ovarian Stimulation for IVF/ICSI. A Prospective Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03007043

Enrollment

364

Registered

2016-12-30

Start date

2016-11-30

Completion date

2019-12-31

Last updated

2020-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fertility Disorders

Brief summary

To evaluate the difference in the prevalence of the main FSHR polymorphism (ASN680Ser), as well as other, less studied, gonadotropin polymorphisms between ovarian response groups, following ovarian stimulation

Interventions

OTHERblood sample

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 38 Years

Healthy volunteers

Inclusion criteria

1. Age between 18-38 years old 2. BMI 18-28 3. Antral follicle count (AFC) \> 9 or Anti-mullerian hormone (AMH) \>1.1 ng/ml 4. 1st or 2nd ovarian stimulation cycle for IVF/ICSI 5. Planned to undergo ovarian stimulation with 150IU of rFSH in a fixed GnRH antagonist protocol

Exclusion criteria

1. Antral follicle count (AFC) \<9 and AMH\<1.1 ng/ml 2. PCOS patients according to the Rotterdam criteria 3. Patients undergoing in vitro maturation (IVM) 4. Untreated endocrine abnormalities

Design outcomes

Primary

Measure	Time frame
prevalence of the main FSH receptor polymorphism	12 months

Countries

Spain, Vietnam

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 15, 2026