Postoperative; Parotitis
Conditions
Brief summary
Opioids are widely used for pain relief after major abdominal surgeries\[1\]. Sex differences in the opioid analgesia have been reported and investigated in human subjects and animal models In this study, effects of sex difference on response to opioid analgesics after abdominal surgeries will be assessed regarding; analgesic duration (primary variable), frequency of analgesic requirement, total opioid consumption, Opioid related complications (respiratory depression, Nausea & vomiting, itching, over-sedation, delayed intestinal motility).
Interventions
DRUGpostoperative morphine
Postoperatively, A loading dose of morphine will be given in incremental doses of 1 mg 5 min apart, till the VAS score reached ≤3. The dose of morphine required to reduce the VAS score to ≤3 will be recorded. Subsequently, PCA pump will be configured to deliver a bolus of 1 mg with a lock-out period lasting for 20 min.
Sponsors
Mansoura University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* ASA I and II Cases scheduled for elective intraabdominal surgeries
Exclusion criteria
* diabetes, * postmenopausal females, * laparoscopic surgery, * regional anesthesia emergency procedures, * sepsis, * hepatectomy, * Renal impairment, and * hepatic impairment, * mental and psychiatric disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative morphine consumption | 24 hours after surgery |
Outcome results
None listed