Clinical Pregnancy Rate
Conditions
Keywords
endometriosis, long term GnRH-a
Brief summary
Gonadotropin-releasing hormone analogue (GnRH-a) is a synthetic decapeptide compound which can down-regulate pituitary function causing a temporary low estrogen state. Since endometriosis is an estrogen-dependent disease, the use of long-acting GnRH-a can control the growth of endometriosis by inhibiting ovary function.Some scholars have found that, for adenomyosis patients who received a super long protocol (pretreatment of long-acting GnRH-a for 1-2 months) in IVF treatment, the pregnancy outcome is comparable to that of the controls with normal uterus. Thus, the aim of this study is to compare the clinical pregnancy rate in patients treated with GnRH-a for 1, or 2 months.
Interventions
DRUGLong term GnRH-a (3.75mg)
patient in this group only receive GnRH-a 3.75 for pituitary down-regulation
Sponsors
The First Affiliated Hospital of Zhengzhou University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
22 Years to 42 Years
Healthy volunteers
No
Inclusion criteria
* first IVF cycle; * with normal ovarian reserve(FSH(10miu/ml； antral follicle count )3) * with normal uterine
Exclusion criteria
* Pre-implantation genetic diagnosis cycles; * Oocyte donation cycles
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical pregnancy rate | 5 weeks after embryo transfer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of oocytes retrieved | 1 day at oocyte retrieved day | — |
| 2 pronucleus(2PN)fertilization rate | 48hours after oocyte retrieved day | Number of 2PN/Matured oocytes |
Countries
China
Contacts
Primary ContactHuijuan Kong, M.D.
Outcome results
None listed