Anesthesia; Reaction, Cornea
Conditions
Keywords
nitrogen protoxide, oxygen, corneal endothelial, pediatric
Brief summary
To evaluate the mean changes in Endothelial Cell and Corneal pachymetry in eyes that operated under N2O + sevoflurane and O2 + sevoflurane general anesthesia.
Detailed description
40 eyes of 40 patients who had extraocular surgery under general anesthesia will be included in this prospective study. Cell density, Cell variatio, Hexagonality rate and pachymetry specular microscopy results at before surgery and 1 week and 1 month after surgery will be analyzed. O2 (1 l/min) with 50% air and N2O (1 l/min) with 50% air will be applied to each group with flow rate 2 l/min totally, respectively. The duration of surgery will be recorded.
Interventions
OTHERNitrogen protoxide
OTHEROxygen
Sponsors
Inonu University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
5 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
* 40 eyes of 40 pediatric patients who had extraocular surgery under general anesthesia
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of corneal endothal number | after surgery at first day, 1th week and 1th month | Nitrogen protoxide and oxygen may be change this number |
| Change of Cell density rate | after surgery at first day, 1th week and 1th month | Nitrogen protoxide and oxygen may be change this rate |
| Change of Cell variation rate | at before surgery and 1 week and 1 month after surgery | Nitrogen protoxide and oxygen may be change this rate |
| Change of Hexagonality rate | after surgery at first day, 1th week and 1th month | Nitrogen protoxide and oxygen may be change this rate |
| Change of pachymetry specular microscopy results | after surgery at first day, 1th week and 1th month | Nitrogen protoxide and oxygen may be change these results |
Outcome results
None listed