Infection, Fungal
Conditions
Brief summary
Fungal infections have increased over the last two decades, largely because of the increasing size of the population at risk, including patients who are immunocompromised, broad-spectrum antibiotics and intravascular catheter users. Essential oils and other extracts of plants have evoked interest as sources of natural products. They have been shown to possess antibacterial, antifungal, antiviral, insecticidal and antioxidant properties. To the best of our knowledge, no study has examined the efficacy of cumin seed extract on relieving vulvovaginal candidiasis in vivo.
Interventions
DRUGCumin seed extract
patients will receive the drug in suppository form
DRUGclotrimazole
patients will receive the drug in suppository form
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 49 Years
Healthy volunteers
No
Inclusion criteria
1. Women were 18-49 years old and were married; 2. They had not used antibiotics, immunosuppressive drugs, or vaginal drugs 14 days before the study; 3. They did not suffer from trichomonal vaginitis, bacterial vaginitis, or cervicitis based on direct smear; 4. Candidiasis culture was in agreement with clinical symptoms and patient's complaints.
Exclusion criteria
1. Pregnant and lactating women; 2. Those who had abnormal uterine bleeding; 3. Women with diabetes or autoimmune diseases; 4. Women refuse to participate in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The percentage of patients with complete cure | one week | cure is defines as absence of symptoms |
Countries
Egypt
Outcome results
None listed