GBM
Conditions
Keywords
GBM; Integrative Analysis; WES
Brief summary
Integrative analysis of GBM
Detailed description
The investigators will analyzed proteomes of paired normal brain tissues and GBM, sequenced transcriptomes, perform whole exome sequencing, and single nucleotide polymorphism (SNP) array profiling for triplets, each comprising normal brain tissue, primary GBM carcinoma, and its synchronous matched metastasis, as well as analyzed genomics of GBM characterized previously by The Cancer Genome Atlas (TCGA) to conduct integrated proteogenomic analyses.
Interventions
OTHERNormal brain tissue
The investigators will extract total protein, DNA and RNA from the samples.
Sponsors
Jilin University
Ganzhou City People's Hospital
Shanghai 10th People's Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Age ≤ 75 years with histologically proven GBM * No severe major organ dysfunction * World Health Organization (WHO) performance status of 0 or 1 * No prior cancer chemotherapy
Exclusion criteria
* Age ≥ 76 * Severe major organ dysfunction * WHO performance status of \>1 * Prior cancer chemotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 5 years overall survival | 5 years |
Secondary
| Measure | Time frame |
|---|---|
| 5 years disease-free survival | 5 years |
| 10 years overall survival | 10 years |
| 10 years disease-free survival | 10 years |
Countries
China
Contacts
Primary ContactDa Fu, PhD
Backup ContactYushui Ma, BS
Outcome results
None listed