Parkinson Disease
Conditions
Keywords
Parkinson Disease, emotional recognition, Deep Brain Stimulation
Brief summary
Parkinson's disease (PD) is usually responsible of cognitive and behavioral non-motor signs with a major impact on the quality of life. Social cognition is a complex system relying on emotion recognition (neurons mirror system, NMS), the theory of mind (with its two parts: emotional and cognitive), but also on the social and cultural environment and the personal history. The first step in this model is represented by the NMS, which seems to be altered in PD patients for both positive and negative emotions as shown in our preliminary study. The investigator purpose is to investigate the role of the treatment (levodopa and deep brain stimulation) on the functioning of the NMS.
Interventions
OTHERNeuropsychological detailed tests with focus on social cognition
MATTIS, MOCA, BREF, Light points test, PDQ39
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Parkinson's disease with motor fluctuations and dyskinesias receiving deep-brain stimulation * Social insurance
Exclusion criteria
* No affiliation to the social insurance * Patients under guardianship
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| variation of the emotional recognition score (point lights test) before deep brain surgery | Baseline |
| variation of the emotional recognition score (point lights test) after deep brain surgery | 1 year |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| PDQ39 score (Parkinson's Disease Questionnaire) | 1 year | Quality of Life |
| MATTIS (dementia rating scale) score | 1 year | Global cognition. The Clinical Dementia Rating or CDR is a numeric scale used to quantify the severity of symptoms of dementia |
Countries
France
Outcome results
None listed