Chronic Obstructive Pulmonary Disease
Conditions
Brief summary
The aim of the study is to determine if increased retrograde shear would further deteriorate the already impaired vascular function in severe COPD patients.
Interventions
OTHERretrograde flow
Two pneumatic cuffs were placed on the experimental arm, one on the lower forearm, and the other on the upper arm. Two cuffs were simultaneously inflated for 20 minutes. The distal cuff was inflated to 75 mm Hg and the proximal cuff was inflated to 40 mm Hg. The contralateral (control) arm was cuff free during this intervention.
OTHERoxygen
Supplemental 100% oxygen administered through a nasal cannula.
Sponsors
University of Split, School of Medicine
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* COPD * chronic hypoxemia
Exclusion criteria
* an acute exacerbation, active respiratory infection or infection of other localisation 6 weeks prior to the visit * relevant coexisting lung disease such as interstitial lung disease, cancer, renal failure, thromboembolic disease or major cardiovascular event during the previous year * informed consent not provided or inability to comply with the study protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from Baseline Brachial Artery Diameter at 10, 20 and 25 minutes | 0,10, 20 and 25 minutes |
| Change from Baseline Microparticle Count at 20 minutes | 0 and 20 minutes |
Outcome results
None listed