A Study to Determine the Effectiveness of Utilizing Intraperitoneal Bupivacaine

A Randomized Double Blinded Study to Determine the Effectiveness of Utilizing Intraperitoneal Bupivacaine: Does it Reduce Post-operative Opioid Use Following Laparoscopic Appendectomy?

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03004222

Enrollment

137

Registered

2016-12-28

Start date

2015-07-31

Completion date

2017-11-30

Last updated

2018-01-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic Appendectomy

Brief summary

The purpose of this research is to determine if spraying a local anesthetic to the cecum after a laparoscopic appendectomy decreases the amount of narcotics (pain medicine) needed after surgery and reduces the time to discharge from the hospital.

Detailed description

The purpose of this study is to determine the effectiveness of using intraperitoneal anesthetic during appendectomy. Subjects will be randomized to receive either 20 mL 0.5% bupivicaine or 20 mL of normal saline (placebo) instilled in the right lower quadrant at the cecum after appendix has been removed. Narcotic consumption will be tracked postoperatively. Hypothesis is that instilling local anesthetic at the cecum during a laparoscopic appendectomy will decrease the amount of narcotic a patient uses postoperatively. Secondarily, this study will attempt to determine if there is a decrease in length of stay for the subjects randomized to the anesthetic infiltration.

Interventions

DRUGBupivacaine

20 ml of 0.5% Bupivacaine

DRUGPlacebos

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients 18 years of age and older * Laparoscopic appendectomy at Metro Health Hospital

Exclusion criteria

* Adults unable to consent Non-English speaking patients * Suspected or known malignant disease * Patients with known allergies to the local anesthetic * Utilizes opioid pain medicine for a chronic condition * Elective laparoscopic appendectomy * Known allergy or contraindication to ketorolac

Design outcomes

Primary

Measure	Time frame
Total narcotic use following surgery until the time of discharge from the hospital.	1, 2, 4 hours

Secondary

Measure	Time frame
Time to Discharge	12 hours
Pain Level Scores at 1, 2, 4, and 12 hours postoperatively	12 hours

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026