Dietary Supplementation
Conditions
Brief summary
This study was designed to examine how different forms of creatine impact active males.
Detailed description
This study examined the effects of different formulations of creatine nitrate on muscle creatine content, body composition, anaerobic exercise capacity, bench press performance and clinical chemistry panels in recreationally active males.
Interventions
DIETARY_SUPPLEMENTCreatine monohydrate
Creatine monohydrate (6.0 g) + dextrose (0.5 g)
DIETARY_SUPPLEMENTCreatine nitrate
Creatine nitrate (5.0 g creatine monohydrate + 1.5 g. creatine nitrate that provides 1.0 g. of creatine and 0.5 g. nitrate in 2:1 ratio)
DIETARY_SUPPLEMENTPlacebo
Placebo (6.5 g dextrose)
Sponsors
Nutrabolt
Texas A&M University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* participants are apparently healthy and recreationally active males between the ages of 18 and 40; * participants will need to have at least six months immediate prior history of resistance training on the bench press and leg press or squat;
Exclusion criteria
* participants have a history of treatment for metabolic disease (i.e., diabetes), hypertension, hypotension, thyroid disease, arrhythmias and/or cardiovascular disease; * participants are currently using prescription medications; * participants have a history of smoking; * participants drink excessively (i.e., 12 drinks per week or more); * participants have a recent history of creatine supplementation within six weeks of the start of supplementation;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effects of 28 Days of Different Forms of Creatine Supplementation on anaerobic capacity | 28 Days | Assessing anaerobic capacity through 6 x 6 second sprints followed by a 30 second sprint on a Wingate bicycle ergometer |
| Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular ATP | 28 Days | Assessing intramuscular Adenosine Triphosphate (ATP) using standard spectrophotometric methods using a microplate spectrophotometer |
| Effects of 28 Days of Different Forms of Creatine Supplementation on muscular strength | 28 Days | Assessing muscular strength through 1 Repetition Maximum (RM) testing |
| Effects of 28 Days of Different Forms of Creatine Supplementation on muscular endurance | 28 Days | Assessing muscular endurance through repetition to failure testing |
| Effects of 28 Days of Different Forms of Creatine Supplementation on Body Water | 28 Days | Assessing Body Water through Bioelectrical Impedance Analysis (BIA) |
| Effects of 28 Days of Different Forms of Creatine Supplementation on Body Composition | 28 Days | Assessing Body Compositing through Dual-Energy X-Ray Absorptiometry (DXA) |
| Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular creatine | 28 Days | Assessing intramuscular creatine using standard spectrophotometric methods using a microplate spectrophotometer |
| Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular phosphocreatine | 28 Days | Assessing intramuscular phosphocreatine using standard spectrophotometric methods using a microplate spectrophotometer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effects of 28 Days of Different Forms of Creatine Supplementation on self-reported side effects | 28 Days | Assessing self-reported side effects using a side effects questionnaire |
| Effects of 28 Days of Different Forms of Creatine Supplementation on blood | 28 Days | Measure standard clinical chemistry panels in the blood to evaluate safety |
| Effects of 28 Days of Different Forms of Creatine Supplementation on training volume (weight lifted x number of repetitions x number of sets) | 28 Days | Assessing training volume using a calculator |
Outcome results
None listed