Insulin Sensitivity, Metabolism Disorder, Obesity, Pediatric
Conditions
Brief summary
Despite exercise training decrease blood fasting glycemia in 'average' terms, there is a wide interindividual variability after exercise training explored mainly in adults but not in children. Thus, is yet unknown what baseline health status as well as the influence of what health variable may produce more/less non-responder (NR) prevalence (i.e., percentage of subjects who experienced a non-change/worsened response after training in some metabolic outcomes) after exercise training in school children.
Interventions
BEHAVIORALHigh Intensity Training (HIT) + Resistance Training (RT)
Exercise will be performed at three sessions per week. Post statistical analyses will be including analyses by the 3 sub-groups proposed. All sessions will be supervised by an exercise physiologist during 6 weeks.
BEHAVIORALControl group
Post statistical analyses will be including analyses by the 3 sub-groups proposed Exercise will be performed at three sessions per week. All sessions will be supervised by an exercise physiologist during 6 weeks.
Sponsors
Healthcare Center Tomas Rojas
Health Service of Los Ríos by the Health promotion program
Universidad Pública de Navarra
Universidad del Rosario
Universidad Santo Tomas
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
9 Years to 13 Years
Healthy volunteers
Yes
Inclusion criteria
* Diagnosed of insulin resistance by one of three plasmatic glucose control: HOMA-IR ≥3.0, * Fasting insulin levels ≥15 µUI/dL or fasting glucose ≥100 and ≤126 mg/dL within the enrolment stage applied at school (i.e., ≤3 months), * Physical inactivity (volume of ≤60 min/day of moderate physical activity), * To be participating of regular practical physical education classes at school (i.e., 90 min/week), * Living only in urban areas.
Exclusion criteria
* Potential medical, musculoskeletal problems or a familial history of T2DM, * Ischemic disease, * Arrhythmia, * Asthma, * Utilization of drugs that modulate the metabolic and respiratory control.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from Baseline in plasma homeostasis model assessment (HOMA-IR) | Baseline and 6 weeks immediately after the interventions ends |
Secondary
| Measure | Time frame |
|---|---|
| Change from Baseline in body mass index | Baseline and 6 weeks immediately after the interventions ends |
| Change from Baseline in waist circumference | Baseline and 6 weeks immediately after the interventions ends |
| Change from Baseline in fat mass | Baseline and 6 weeks immediately after the interventions ends |
| Change from Baseline in blood pressure | Baseline and 6 weeks immediately after the interventions ends |
| Change from Baseline in fasting glucose | Baseline and 6 weeks immediately after the interventions ends |
| Change from Baseline in body mass | Baseline and 6 weeks immediately after the interventions ends |
| Change from Baseline in one maximum repetition strength test of leg-extension exercise | Baseline and 6 weeks immediately after the interventions ends |
| Change from Baseline in one maximum repetition strength test of shoulder press exercise | Baseline and 6 weeks immediately after the interventions ends |
| Change from Baseline in one maximum repetition strength test of upper-row exercise | Baseline and 6 weeks immediately after the interventions ends |
| Change from Baseline in one maximum repetition strength test of biceps curl exercise | Baseline and 6 weeks immediately after the interventions ends |
| Change from Baseline in fasting insulin | Baseline and 6 weeks immediately after the interventions ends |
Countries
Colombia
Outcome results
None listed