Critical Illness
Conditions
Keywords
Hyperglycemia, Fructose, Diabetes mellitus, Enteral Nutrition, Glycemic Variability
Brief summary
Hyperglycemia is a known risk factor for mortality in critically ill patients. Most of these patients receive enteral feeding. There is controversy about ideal carbohydrate composition of these diets. The aim of this study was to compare an enteral formula with the same proportion of carbohydrates with and without fructose on blood glucose levels.
Detailed description
Randomized, cross-over, controlled, double-blind clinical trial without washout. Adult patients admitted to the ICU who presented capillary glycemia values\> 180mg / dl with a full and exclusive enteral diet. They were randomized and observed for 4 days (2 days with each diet: with / without fructose). Capillary glycemia was measured 4 / 4h.
Interventions
DIETARY_SUPPLEMENTEnteral Formula With Fructose
Low-carbohydrate Enteral Formula With Fructose
DIETARY_SUPPLEMENTEnteral Formula Without Fructose
Low-carbohydrate Enteral Formula Without Fructose
Sponsors
Hospital Moinhos de Vento
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Critical Illness * Exclusive enteral diet * Enteral diet with full nutritional value * Hyperglycemia ≥180 mg / dl
Exclusion criteria
* Oral feeding * NPT (Total or Partial Parenteral Nutrition) * Patient without indication of use of study diets
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glycemic Variability | four days | To evaluate the glycemic oscillation during the use of enteral feedings |
Outcome results
None listed