Abdominal Neoplasms
Conditions
Brief summary
the investigators aim is to investigate the effect of continuous preperitoneal bupivacaine wound infiltration versus epidural analgesia on the inflammatory cytokines response following radical cytectomy
Interventions
DEVICEepidural catheter
DEVICEpreperitoneal catheter
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* ASA I-III patients * aged 18-60 yr * undergo open abdominal cancer surgery
Exclusion criteria
* general contraindications for epidural analgesia, * recent history (8 weeks) of, chemotherapy or radiation, * chronic opioid use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes in the level of inflammatory cytokines in pg /ml | 24 hours | Blood samples taken all over the 24-hr. period were collected in plasma tubes containing ethyl-enediamine-tetra-acectic (EDTA), centrifuged and stored at 20○c for assessment of Plasma concentrations plasma IL 1, IL 6, IL10 and TNF to assess inflammatory cytokines |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| patient satisfaction | 24 hours | scale ranging 1-4 :unsatisfactory, regular, satisfactory and excellent) |
| Visual Analog Scale at rest and on coughing | 24 hours | pain intensity was assessed using a 10-cm VAS (0 = no pain and 10 = worst imaginable pain) |
| opioid side-effects | 24 hours | observation of side effects and record incidence as nausea, vomiting and itching |
Countries
Egypt
Outcome results
None listed