Anesthesia
Conditions
Keywords
anesthesia, neurodevelopment, dental caries
Brief summary
The purpose of this study is to investigate whether early expose to general anaesthesia will influence neurodevelopment.
Detailed description
Participants, according to the state of illness and clinical requirements, assigned to receive dental caries treatment with or without general anesthesia. During the follow-up, various of neurodevelopment assessment will be done at specific timepoint to investigate whether general anaesthesia will influence neurodevelopment.
Interventions
PROCEDUREgeneral anesthesia
nitrous oxide, sevoflurane, propofol, cisatracurium, fentanyl for induction and maintenance with sevoflurane
Sponsors
Air Force Military Medical University, China
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
2 Years to 6 Years
Healthy volunteers
No
Inclusion criteria
* Gestational age\>=36 weeks * American Society of Anesthesiologists（ASA） physical status Ⅰ or Ⅱ，with very limited systemic disease. * Age\<=6 yr
Exclusion criteria
* did not provide research authorization； * unable to contact or inconvenient for follow-up; * hypersensitive to general anesthesia drug; * previous exposure to general anesthesia in utero; * previous exposure to general anesthesia as a neonate * previous exposure to psychotropic medication; * complications at birth such as low weigh, hypoxia, or cerebral edema; * any other known diseases may influence the neurodevelopment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Full Scale Intelligence Quotient (IQ) | 24-28 weeks after enrollment | according to Wechsler Preschool and Primary Scale of Intelligence fourth edition (WPPSI-IV) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Working Memory Index | 24-28 weeks after enrollment | according to WPPSI-IV |
| Verbal Comprehension Index | 24-28 weeks after enrollment | according to WPPSI-IV |
| Visual Spatial Index | 24-28 weeks after enrollment | according to WPPSI-IV |
| Fluid Spatial Index | 24-28 weeks after enrollment | according to WPPSI-IV |
| Executive Function | 24-28 weeks after enrollment | according to Behavior Rating Inventory of Executive Function-Preschool Version (BRIEF-P) |
| Adaptive Behavior | 24-28 weeks after enrollment | according to Adaptive Behavior Assessment System second edition |
| Emotion Comprehension | 24-28 weeks after enrollment | according to Test of Emotion Comprehension(TEC) (designed by Pons & Harris ,2000) |
| Processing Speed Index | 24-28 weeks after enrollment | according to WPPSI-IV |
Countries
China
Contacts
Primary ContactHui Zhang, M.D.
Outcome results
None listed