Coronary Artery Bypass Graft
Conditions
Brief summary
In this study, the investigators propose to investigate a novel technique for fluid responsiveness prediction. It is based on the occurrence of an extra systole, which induces a preload variation: Extra systoles are comprised by, first, the premature/ectopic beat with decreased cardiac preload, then, the post-ectopic beat with moderately increased preload. Consequently, the post ectopic beat is associated with a Frank-Starling curve right shift but is otherwise a normal sinus beat. As such, the post-ectopic beat elucidates and predicts the hemodynamic effect of increasing preload, i.e. giving fluids
Interventions
OTHERfluid challenge
At two pre-defined time points during the procedure, enrolled patients will receive a fluid bolus of 5 ml/kg during 5 minutes
Sponsors
University Medical Center Groningen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients requiring elective CABG or OPCAB surgery * Patient's age ≥ 18 years
Exclusion criteria
* Patient refusal * Pregnancy * EF \< 35% * End stage kidney failure (defined by the need for haemodialysis) * Patients with atrial fibrillation or frequent and coupled extra systoles (e.g. trigemini)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fluid challenge response in stroke volume | during operation | To investigate if post-ectopic induced changes in blood pressure before a fluid bolus (5 ml/kg) predicts the fluid induced change in cardiac stroke volume |
Countries
Netherlands
Outcome results
None listed