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High Quality Evidence of Chinese Lupus Nephritis (HELP)

High Quality Evidence of Chinese Lupus Nephritis (HELP)

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03001973
Enrollment
5000
Registered
2016-12-23
Start date
2013-11-01
Completion date
2029-12-01
Last updated
2026-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lupus Nephritis

Keywords

Lupus nephritis, Patient survival, Renal survival

Brief summary

The investigators are registering LN patients at recruited hospitals and developing a LN database in China. Patients will be follow-up every year, and both baseline and follow-up information will be entered into the registration system.

Detailed description

The investigators are registering Lupus nephritis (LN) and developing a LN database in China. Patients' demographic characteristics (including age, gender, height, weight, BMI, smoking, drinking, and education etc.), clinical characteristics (including systolic blood pressure, diastolic blood pressure, and lab measurements of whole blood, serum, urine etc.), complications, drug information at the baseline will be collected. Patients will be follow-up every year, the demographic and clinical characteristics, complications; drug information of patients will be collected at each visit. We will also record the outcome at each visit, such as mortality (including all-cause mortality and cardiovascular disease mortality), end-stage renal disease (ESRD) or serum creatinine doubling. The patient survival and renal survival will be compared using the LN database.

Interventions

OTHERNo Intervention

Registration of all LN patients in the First Affiliated Hospital of Sun Yat-sen University and other hospitals which have signed the contract in China.

Sponsors

Sun Yat-sen University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
14 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Patients who diagnosis as lupus nephritis

Exclusion criteria

* No

Design outcomes

Primary

MeasureTime frameDescription
All-cause mortality and cardiovascular mortality of LN patients10years
A composite renal outcome of LN patients10yearsThe composite renal outcome defined as doubling of serum creatinine and ESRD (defined as initiation of dialysis or kidney transplantation).

Countries

China

Contacts

CONTACTXueqing Yu, M.D. & Ph.D
yuxq@mail.sysu.edu.cn
CONTACTWei Chen, M.D. & Ph.D
vvchen66@qq.com8620-87755766

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 16, 2026