Infertility, Preimplantation Genetic Screening
Conditions
Brief summary
This is a single centre retrospective study in repeated implantation failure patients: \< 39 years old, at least 4 D3 good quality embryos or 2 good quality blastocysts transferred without implantation, absence of known causes of implantation failures (uterine malformation, thrombophilia, severe male factor, uncontrolled thyroid disfunction, autoimmune disease). Patients scheduled for PGS underwent one or more stimulation cycles (oocyte or blastocyst banking) in order to maximize chances of embryo transfer. PGS cycles are analyzed globally. Aditionally, PGS cycles with a single stimulation cycle are analyzed in comparison to standard IVF cycles.
Interventions
PROCEDUREPGS (Preimplantation Genetic Screening) with trophectoderm biopsy
PGS (Preimplantation Genetic Screening) with trophectoderm biopsy using arrays comparative genomic hybridizatioon (aCGH)
Sponsors
Fundacion Dexeus
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 38 Years
Healthy volunteers
No
Inclusion criteria
* women \< 39 years * repeated implantation failure: at least 4 day 3 good quality embryos or 2 good quality blastocysts transferred without implantation
Exclusion criteria
* partner with severe male factor, or abnormal sperm Fluorescence in situ hybridization (FISH) analysis * presence of uni or bilateral hydrosalpinx, uterine malformation, thrombophilia, uncontrolled thyroid disfunction or autoimmune disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative live birth rate | at 24 months of first embryo transfer |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Pregnancy Rate | 6 weeks after embryo transfer |
| Implantation Rate | 6 weeks after embryo transfer |
| Miscarriage Rate | Until 20 weeks after embryo transfer |
Countries
Spain
Outcome results
None listed