Thyroid Function and Diabetes Complications

Association Between Thyroid Function and Diabetes Complications in Elderly Patients With Type 2 Diabetes Mellitus in China

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03001336

Enrollment

260

Registered

2016-12-23

Start date

2010-12-31

Completion date

2013-05-31

Last updated

2016-12-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes, Thyroid Disease

Keywords

Thyroid, Diabetes Mellitus

Brief summary

The purpose of this study is to investigate the potential association between thyroid function and diabetes complications in the elderly subjects with type 2 diabetes mellitus (T2DM).

Detailed description

Aims: We investigated the potential association between thyroid parameters and microalbuminuria in the euthyroid elderly subjects with type 2 diabetes mellitus (T2DM). Subjects: Elderly inhospital patients with T2DM who visited in the Department of Endocrinology at the Nanjing First Hospital from January 2011 to December 2012. Methods: Clinical factors, serum levels of glucose, lipids, free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroid autoantibodies,24h urine albuminuria and fluorescence fundus angiography are conducted. The relationships levels of thyroid function and diabetic complications are analysed.

Interventions

OTHERno intervention

This is a cross-sectional study

Study design

Observational model

ECOLOGIC_OR_COMMUNITY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Patients are ≥ 60 years old, with T2DM and the diagnostic criteria of T2DM is according to the World Health Organization in 1999. 2. Patients have normal thyroid function and negative for thyroid autoantibodies, such as thyroid peroxidase antibody (TPOAb) or thyroglobulin antibody (TGAb).

Exclusion criteria

1. Patients with a history of thyroid disease or chronic liver disease or nondiabetic renal problems or cancer. 2. Patients use systemic drug therapy such as thyroxine, anti-thyroid drugs, glucocorticoids and oral contraceptives. 3. Patients are pregnant or lactating women. 4. Patients with acute intercurrent illness of diabetes. 5. Patients with an acute infection. 6. Patients with a history of drug abuse alcohol dependence in the past 5 years.

Design outcomes

Primary

Measure	Time frame
Diabetic retinopathy which is diagnosed by the measurement of fundus fluorescein angiography. (Diabetic retinopathy is clinically graded based on the international clinical diabetic retinopathy severity scales.)	Day One

Secondary

Measure	Time frame
24h-albuminuria	Day One

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026