Acute Effect of Agiotensin-(1-7) in Healthy and Hypertensive Subjects

Acute Effect of Agiotensin-(1-7) on Bood Pressure and Heart Rate in Healthy and Hypertensive Subjects

Status

UNKNOWN

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03001271

Acronym

Ang-(1-7)

Enrollment

Registered

2016-12-23

Start date

2014-01-31

Completion date

2017-03-31

Last updated

2016-12-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Keywords

Angiotensin-(1-7), Renin-angiotensin System, Autonomic Nervous System

Brief summary

In the modern concept of Renin-angiotensin System, Angiotensin-(1-7) plays a key role and demonstrates promising therapeutic potential due to it is generally opposite effects to Angiotensin II. The aim is to evaluate the effect of Ang-(1-7) acute administration on systolic and diastolic blood pressure (SBP and DBP) and heart rate (HR) in healthy and hypertensive subjects.

Interventions

DRUGAngiotensin 1-7

OTHERPlacebo

Study design

Allocation

NON_RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy Group Inclusion Criteria: * arterial pressure \<140/90 mmHg * body mass index (BMI) between 18,5 and 29 Kg/m2 Hypertensive Group Inclusion Criteria: * anti-hypertensive drug treatment * ambulatory blood pressure monitoring (ABMP) \>130/85 mmHg * body mass index between 18,5 and 29 Kg/m2 Healthy Group

Exclusion criteria

* drug treatment * recent surgeries * pregnancy * previous cardiovascular events * high performance athletes * dislipidemia * diabetes * renal injury * obesity (BMI above 30 kg/m2) * alcoholism * smoking. Hypertensive Group

Design outcomes

Primary

Measure	Time frame
Absence of adverse effects after Ang-(1-7) acute administration	Along 25 hours

Secondary

Measure	Time frame	Description
Blood Pressure Changes after Ang-(1-7) administration	Recording along 24 hours	absence of measure changes in blood pressure or heart rate (increase or decrease)
Ang-(1-7) effects on Blood Pressure Variability	Along 1 hours after Ang-(1-7) acute administration	Response of autonomic nervous system, registered for 1 hours, after Ang-(1-7) acute administration
Heart Rate Changes after Ang-(1-7) administration	Recording along 24 hours	—
Ang-(1-7) effects on Heart Rate Variability	Along 1 hours after Ang-(1-7) acute administration	Response of autonomic nervous system, registered for 1 hours, after Ang-(1-7) acute administration

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026