Colonic Polyps
Conditions
Keywords
Colonic Polyps, Endoscopic Mucosal Resection, Colonoscopy
Brief summary
This study evaluates the efficacy of small colorectal polyp removal using cold endoscopic mucosal resection with hot endoscopic mucosal resection. Half of the participants will receive cold endoscopic mucosal resection, while the other half will receive hot endoscopic mucosal resection.
Detailed description
Colorectal polyps are considered as precancerous lesions and endoscopical resection is currently the treatment of choice when it is possible. Colorectal polyps are classified into diminutive polyps (\<5mm in diameter), small polyps (6-9mm in diameter), and large polyps (\>1cm in diameter). There are several endoscopical treatment methods: cold biopsy forceps polypectomy, cold snare polypectomy, hot biopsy forceps polypectomy, hot snare polypectomy, and endoscopic mucosal resection. Cold polypectomy means mechanical removal of the polyp with snare or biopsy forceps without the use of electrocautery, and hot polypectomy means removal of the polyp with the use of electocautery.
Interventions
PROCEDURECold endoscopic mucosal resection
Cold endoscopic mucosal resection (EMR) means removing small colorectal polyps (\<1cm) with snare without the use of electocautery after injection of normal saline into the submucosa.
PROCEDUREHot endoscopic mucosal resection
Hot endoscopic mucosal resection (EMR) means removing small colorectalpolyps (\<1cm) with snare without the use of electocautery after injection of normal saline into the submucosa.
Sponsors
Chonnam National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with colorectal polyps that are \<1cm in diameter who need endoscopic mucosal resection. * Patients who gave informed consents to this study.
Exclusion criteria
* Patients under the age of 19 * Patients who are receiving antiplatelet or anticoagulant therapies * Patients with hypercoagulability (i.e., liver cirrhosis, hemophilia, end-stage renal disease, or chronic kidney disease)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Complete removal of the colorectal polyp | At the time of the procedure (endoscopic mucosal resection) | The resected specimen will be reviewed microscopically to assess complete resection including the lateral and base margins |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Procedure time | At the time of the procedure (endoscopic mucosal resection) | The time needed for the hot EMR vs cold EMR (minutes) will be assessed. |
| Complication after endoscopic mucosal resection | Within 1 month | Procedure-related complications (bleeding, perforation, and post-coagulation syndrome) will be assessed. |
Countries
South Korea
Outcome results
None listed