Assessment of Different Forms of Creatine

Pharmacokinetic Assessment of Acute Ingestion of Different Forms of Creatine

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03000582

Acronym

NB3

Enrollment

Registered

2016-12-22

Start date

2014-06-30

Completion date

2014-09-30

Last updated

2016-12-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dietary Modification

Brief summary

The purpose of this study is to examine the pharmacokinetics of creatine nitrate supplementation.

Detailed description

Creatine nitrate contains several nutrients that may increase anaerobic exercise performance. Theoretically, dietary supplementation of creatine nitrate during resistance training can improve the quality of training leading to greater changes in strength, power and fat free mass. Endothelial function measured by flow-mediated dilation (FMD), a non-invasive vascular health parameter that can be measured via ultrasonography, is a predictor of cardiovascular disease risk which precedes traditional risk markers. Diet, physical activity and pharmaceutical interventions can all impact vascular function and health. The purpose of this study is to determine the acute vascular response of creatine nitrate supplementation on FMD by analyzing the pharmacokinetics of creatine nitrate supplementation.

Interventions

DIETARY_SUPPLEMENTCreatine monohydrate

Creatine monohydrate (5.0 g creatine monohydrate, 1.5 g dextrose)

DIETARY_SUPPLEMENTCreatine nitrate-1

Creatine nitrate-1 (1.0 g creatine monohydrate, 0.5 g nitrate, 5.0 g dextrose)

DIETARY_SUPPLEMENTCreatine nitrate-2

Creatine nitrate-2 (2.0 g creatine monohydrate, 1.0 g nitrate, 3.5 g dextrose)

DIETARY_SUPPLEMENTPlacebo

Placebo (6.5 g dextrose)

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

DOUBLE (Subject, Investigator)

Eligibility

Healthy volunteers

Yes

Inclusion criteria

* you are an apparently healthy and recreationally active male between the ages of 18 and 40;

Exclusion criteria

* you have a history of treatment for metabolic disease (i.e., diabetes), hypertension, hypotension, thyroid disease, arrhythmia and/or cardiovascular disease; * you are currently using prescription medications; * you have a history of smoking; * you drink excessively (i.e., 12 drinks per week or more); * you have a recent history of creatine supplementation within six weeks of the start of supplementation;

Design outcomes

Primary

Measure	Time frame
Examine creatine vs. creatine nitrate supplementation by assessing flow-mediated dilation (FMD) via ultrasonography	One day
Examine creatine vs. creatine nitrate supplementation by assessing body composition	One day
Examine creatine vs. creatine nitrate supplementation by assessing serum creatine levels	One day
Examine creatine vs. creatine nitrate supplementation by assessing serum nitrate levels	One day
Examine creatine vs. creatine nitrate supplementation by assessing serum nitrite levels	One day
Examine creatine vs. creatine nitrate supplementation by assessing body water	One day

Secondary

Measure	Time frame
Measure side effects to evaluate safety utilizing a side effects questionnaire	One day
Measure heart rate to evaluate safety	One day
Measure blood pressure to evaluate safety	One day
Measure standard clinical chemistry panels in the blood to evaluate safety	One day

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026