Hypertension, Metabolism Disorder
Conditions
Brief summary
Despite exercise training decrease blood pressure in 'average' terms, there is a wide interindividual variability after exercise training, being yet unknown what mode of exercise (e.g. endurance, strength, concurrent, or high intensity interval training) produce more/less non-responder (NR) prevalence (i.e., percentage of subjects who experienced a non-change/worsened response after training in some outcome).
Detailed description
Despite exercise training decrease blood pressure in 'average' terms, there is a wide interindividual variability after exercise training, being yet unknown what mode of exercise (e.g. endurance, strength, concurrent, or high intensity interval training) produce more/less non-responder (NR) prevalence (i.e., percentage of subjects who experienced a non-change/worsened response after training in some outcome).
Interventions
BEHAVIORALHigh Intensity Interval Training
High Intensity Interval Training pre-hypertensive group; Exercise will be performed at three sessions per week. All sessions will be supervised by an exercise physiologist during 16 weeks.
BEHAVIORALControl group
Moderade Intensity Interval Training pre-hypertensive group; Exercise will be performed at three sessions per week. All sessions will be supervised by an exercise physiologist during 16 weeks.
Sponsors
Healthcare Center Tomas Rojas
University of Los Ríos
Universidad Pública de Navarra
Universidad del Rosario
Universidad Santo Tomas
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Written informed consent; * Interested in improving health and fitness; * Systolic blood pressure \> 120 mmHg and \< 140 mmHg, and/or DBP ≥ 80 and \< 90 mmHg according with standard classification; * No drug therapy during the previous 3 months; * Body mass index (BMI) 25 and 35 kg/m2); (c) physically inactive (according to the International Physical Activity Questionnaire previously validated in Chilean population) * Normal /mild altered lipid profile (total cholesterol \[TC\] \ 200 and ≤250 mg/dL, low-density lipids \[LDL-C\] \ 140 mg/dL and ≤200 mg/dL, high-density lipids \[HDL-C\] ≥20 and \ 40 mg/dL, triglycerides \ 150 and ≤250 mg/dL) according with standard classification.
Exclusion criteria
* Cardiovascular contraindications to exercise histories of stroke; * Asthma and chronic obstructive pulmonary disease; * Musculoskeletal disorder such as low back pain; * Smokers in the last 3 months were not included in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline in systolic blood pressure and diastolic blood pressure | Baseline and 16 weeks immediately after the interventions ends | After this, we calculated the delta changes in both variables and classified to all subjects in responders (R) and non-responders (NR) to decrease systolic or diastolic blood pressure. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline in body mass index | Baseline and 16 weeks immediately after the interventions ends | BMI will be calculated as the body weight in kilograms divided by the square of the height in meters. |
| Change from Baseline in waist circumference | Baseline and 16 weeks immediately after the interventions ends | — |
| Change from Baseline in fat mass | Baseline and 16 weeks immediately after the interventions ends | — |
| Change from Baseline in body mass | Baseline and 16 weeks immediately after the interventions ends | — |
| Change from Baseline in fasting glucose | Baseline and 16 weeks immediately after the interventions ends | — |
| Change from Baseline in lipids | Baseline and 16 weeks immediately after the interventions ends | Lipid profile (low-density cholesterol, total cholesterol, high-density cholesterol and triglycerides) |
| Change from Baseline in one maximum repetition strength test of leg-extension exercise | Baseline and 16 weeks immediately after the interventions ends | — |
| Change from Baseline in heart rate at rest | Baseline and 16 weeks immediately after the interventions ends | Baseline and 16 weeks immediately after the interventions ends |
Countries
Chile
Outcome results
None listed