Physical Exercise
Conditions
Brief summary
The purpose of this study is to examine how different levels of physical activity impact the ovarian reserve during the pre-menopausal period
Detailed description
Two groups are included: 1. The study group: women between 20-35 years of age who practice high level of physical activity, as defined by International Physical Activity Questionnaire , for the past 3 years 2. The control group: women between 20-35 years of age who practice low level of physical activity, as defined by International Physical Activity Questionnaire , for the past 3 years Women who meet the criteria for inclusion for will be recruited to the study after signing a consent form. Recruitment will be done through sport centers. The control group will include women being examined in gynecologic emergency department, after signing a consent form, if they meet the control group's inclusion criteria. These women will be asked to fulfill the International Physical Activity Questionnaire and additional questionnaire regarding relevant demographic and medical information (see below). Blood samples to anti-mullerian hormone , leptin, and hormonal profile will be obtained in day 3 of menstruation. Ultrasound will be performed to measure Antral Follicular count and ovarian blood flow. Data collection: 1. Demographic information on age, weight, height, BMI, marital status 2. Medical information regarding chronic diseases and medications 3. Obstetrical history 4. Information regarding physical activities in the version of International Physical Activity Questionnaire . 5. Information about menstrual behavior: irregularity (yes/no) frequency (less than 21 days between 21-35 days, over 35 days), menstrual duration (less than 3 days 3-7 days, or over 7 days) bleeding amount according to the number of pads per day (up to 1, 2, 4 or 5 pads). 6. Hormonal profile - Follicle-stimulating hormone , Luteinizing hormone , progesterone, Estradiol, Thyroid-stimulating hormone . 7. Antral Follicle Count, Anti-mullerian hormone 8. Leptin levels -reflecting metabolic changes.
Interventions
OTHERPhysical exercise
Women who practice high level of physical activity, as defined by International Physical Activity Questionnaire, for the past 3 years will be recruited. These women will will be asked to fulfill the International Physical Activity Questionnaire and additional questionnaire regarding relevant demographic and medical information. Blood samples to anti-mullerian hormone , leptin, and hormonal profile will be obtained in day 3 of menstruation. Ultrasound will be performed to measure Antral Follicular count and ovarian blood flow
Sponsors
Meir Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
Study group: 1. Women between 20-35 years of age who practice high level of physical activity, as defined by International Physical Activity Questionnaire, for the past 3 years 2. BMI 18-25 3. Regular menstruation Control group: 1. Women between 20-35 years of age who practice low level of physical activity, as defined by International Physical Activity Questionnaire, for the past 3 years 2. BMI 18-25 3. Regular menstruation
Exclusion criteria
1\. Polycystic ovary syndrome 2. Endometriosis 3. Diabetes 4. Hyper/hypothyroidism 5. BMI\>25, BMI\<18 6. Active or past eating disorder \-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of anti-mullerian hormone | 3 days after period |
| Number of Antral Follicle Count | 3 days after period |
Secondary
| Measure | Time frame |
|---|---|
| Levels of progesterone | 3 days after period |
| Levels of estradiol | 3 days after period |
| Levels of Thyroid-stimulating hormone | 3 days after period |
| Levels of Follicle-stimulating hormone | 3 days after period |
| Menstrual duration | 3 days after period |
| frequency of bleeding in every menstruation | 3 days after period |
| amount of bleeding in every menstruation | 3 days after period |
| Levels of leptin | 3 days after period |
| levels fo Luteinizing hormone | 3 days after period |
Contacts
Primary ContactAmir Wiser, MD
Backup ContactHelsinki Committee MMC
Outcome results
None listed