Ovary Inflammation
Conditions
Brief summary
A molecular study of follicular fluid aspirated from ovarian follicles during routine in vitro fertilization treatment, after the eggs were identified and separated.
Detailed description
Ovarian stimulation is a routine part of in vitro fertilization treatment: this process involves an inflammatory response in the developing follicles. We still do not completely understand the complex interactions leading to the maturation of the egg and the multiple interactions of the egg with its supporting cells. In this study we will assess follicular fluid, letf over after the eggs were identified and separated, for the presence of inflammatory mediators, dendritic cells , vasorin and soluble Flt1. The presence and quantification of these factors, as well as their correlation with the size of the aspirated follicle is the focus of this study.
Interventions
PROCEDUREOvum pickup
Ovum pickup or Egg retrieval, that is performed not for the purpose of the study, but for the purpose of well known in vitro fertilization indications
Sponsors
Weizmann Institute of Science
Meir Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* All women going through a fertility/ fertility preservation indicated egg retrieval in the in vitro fertilization (IVF) unit in 'Meir medical center', * Patients' informed consent
Exclusion criteria
* Patients refusing to take part in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Soluble Vasorin levels | 24 hours post egg retrieval |
| Soluble Flt 1 levels | 24 hours post egg retrieval |
| Dendritic cells quantification | 24 hours post egg retrieval |
Countries
Israel
Contacts
Primary ContactAnat Hershko Klement, MD
Outcome results
None listed