Oral Glucose Tolerance
Conditions
Brief summary
Assess the impact of chronic use of aspartame on glycemia, appetite and body composition.
Detailed description
Participants will be randomly assigned to one of three parallel arms: 0% (water), 5 mg, 15mg aspartame. Participants will have an oral glucose tolerance test at the beginning and end of a 12 week intervention. . Participants will report to the lab weekly for 12 weeks to pick up their next week's intervention products and measurements for body weight, waist circumference, blood pressure and heart rate. They will consume their intervention products daily for 12 weeks. They will record appetite sensations and collect a 24 hour urine sample at weeks 0, 4, 8, and 12.
Interventions
OTHERaspartame
will be given 5mg aspartame or 15 mg aspartame
OTHERwater
control group
Sponsors
Ajinomoto USA, INC.
Purdue University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 18-25 * Fasting blood sugar between 72 and 108 mg/dl via capillary finger-stick.
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change oral glucose tolerance | week 0 4 hours | sample taken at time point 0 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Appetite | every hour for 1 day at week 0 | questionnaire on hunger, fullness, desire to eat, prospective consumption, thirst taken hourly for one day. |
| Body composition | week 0 | body composition measurement Plysmography (BOD POD) |
Countries
United States
Outcome results
None listed