Ocular Surface Disease
Conditions
Keywords
ocular surface sensitivity
Brief summary
A new liquid jet aesthesiometer prototype was developed with the aim to measure ocular surface sensitivity by employing a liquid jet. This study aims to validate this new prototype by means of correlating its measurement with a previously validated air jet aesthesiometer, the non-contact aesthesiometer (NCCA; by Murphy et al. 1996) and by exploring the repeatability of ocular surface sensitivity measurement.
Detailed description
Currently, no aesthesiometer is available that delivers reliable and repeatable measurement of ocular surface sensitivity in a routine clinical setup. The only commercially available Cochet- Bonnet aesthesiometer uses a tactile-mechanical stimulus (the tip of a nylon thread), which can cause a microerosion when applied to the corneal surface. Additional disadvantages represent poor stimulus reproducibility, a limited stimulus bandwidth and the influence of humidity and age on the bending capibility of the nylon thread. For research purposes prototypes of non-contact air aesthesiometers (eg by Murphy et al. and Belmonte et al) are being used. This study aims to correlate ocular surface sensitivity measurements of a newly developed prototype, the liquid jet aesthesiometer, with the non-contact air jet aesthesiometer by Murphy et al. 1996 and to explore its repeatability of measurement. In this repeated measures design 60 subjects participate in corneal sensitivity measurements during two appointments with each described aesthesiometer.
Interventions
None listed
Sponsors
University of Applied Sciences and Arts Northwestern Switzerland
Study design
Observational model
OTHER
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Ocular surface index score \< 13.0
Exclusion criteria
* systemic disease such as diabetes, diseases, injuries and operations in the anterior segment of the eye * systemic medication and / or eyedrops / ointments that may have an influence of the tearfilm. * contact lens wear less than 48 hours before commencement of study measurements.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation with air jet aesthesiometry | two measurements / repeated measures within one month | correlation between corneal sensitivity measurements between liquid jet and air jet aesthesiometry |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| repeatability of corneal sensitivity measurement with new prototype | two measurements / repeated measures within one month | repeatability of corneal sensitivity measurement with liquid jet aesthesiometry |
Outcome results
None listed