Pupillary Diameter Under Different Concentrations of Propofol

Pupillary Diameter Without Stimulation Under Different Concentrations of Propofol Alone

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02998424

Enrollment

Registered

2016-12-20

Start date

2016-05-31

Completion date

2016-12-31

Last updated

2018-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Keywords

propofol, pupillary diameter

Brief summary

Resting pupillary diameter was measured at a randomized Effect-site target concentration of propofol used as a sole anesthetic.

Interventions

DRUGPropofol

Continuous infusion

DEVICEPupillary diameter measurement

Instantaneous measure

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

13 Years to 50 Years

Healthy volunteers

Inclusion criteria

* patient who has reached puberty * ASA I or II who is scheduled for elective surgery under general anesthesia

Exclusion criteria

* neurologic, metabolic, ocular disease * chronic pain * under medication that interferes with autonomic nervous system * obesity * patient requiering a rapid sequence induction

Design outcomes

Primary

Measure	Time frame
Pupillary diameter	Instantaneous measure, 10 minutes after the beginning of the study period

Secondary

Measure	Time frame	Description
Bispectral Index (BIS)	continuous measure, recorded10 minutes after the beginning of the study period	—
Heart rate	continuous measure, recorded10 minutes after the beginning of the study period	—
Observer's Assessment of Alertness/Sedation Scale (OAAS)	10 minutes after the beginning of the study	Clinical score

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026