Postoperative Delirium, Postoperative Cognitive Dysfunction
Conditions
Brief summary
The long-term goal of this study is to evaluate cognitive function preoperatively and develop techniques of intervention in the perioperative period which would optimize brain function and functional recovery following surgery.
Detailed description
In this protocol, subjects who are anticipated to be operated for hip fracture will be studied after surgery. Brief cognitive exam will be done followed by fMRI of connectivity and diffusion tensor imaging (DTI). Connectivity (neuronal changes) and DTI (Anisotropy and mean diffusivity) data will be compared with age matched controls and correlated with subjective measures of cognition.
Interventions
BEHAVIORALfMRI
fMRI for measuring function connectivity and DTI will be done between day 2 to day 5.
BEHAVIORALMontreal Cognitive Assessment (MoCA)
A measure of general cognition
BEHAVIORALDigital Clock Drawing Test Command and Copy
A measure of current cognition using digital pen technology
BEHAVIORALWide Range Achievement Test reading subtest
A measure of premorbid intellectual estimate
BEHAVIORALHopkins Verbal Learning Test (HVLT)
A measure of declarative memory
BEHAVIORALGeneral Depression Scale (GDS)
A measure of the of presence of depression.
Sponsors
University of Florida
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
65 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Patients 65 years and older * Patients who have fracture hip and are anticipated to have surgery
Exclusion criteria
* Patients who have contraindications for MRI like pacemaker, automatic implanted cardiac defibrillator (AICD), implanted infusion pumps etc. * Patients who are claustrophobic * Patients with severe cognitive impairment (who may not be able to cooperate during the cognitive exam and fMRI)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes between baseline and follow up visits as assessed by fMRI | Change from baseline up to 90 days | fMRI for measuring function connectivity and DTI |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes between baseline and follow up visits as assessed by MoCA | Change from baseline up to 90 days | A measure of general cognition |
| Changes between baseline and follow up visits as assessed by Digital Clock Drawing Test Command and Copy | Change from baseline up to 90 days | a measure of current cognition using digital pen technology |
| Changes between baseline and follow up visits as assessed by Wide Range Achievement Test reading subtest | Change from baseline up to 90 days | A measure of premorbid intellectual estimate |
| Changes between baseline and follow up visits as assessed by HVLT | Change from baseline up to 90 days | A measure of declarative memory |
Countries
United States
Outcome results
None listed