Blood Stem Cell Transplant Failure, Multiple Myeloma
Conditions
Brief summary
This is a retrospective observational cohort database analysis. The study will review retrospectively the records of patients undergoing a first peripheral blood stem cell mobilization for multiple myeloma in the databases from approximately 15 hospitals which are part of the IFM collaborative group. Patient records will be divided into two groups of 50 patients minimum, maximum 100 patients or up to the number of patient records that could be extracted. The first group of patients will have received plerixafor plus G-CSF without the administration of chemotherapy as a mobilization strategy and a second group of patients will have received cyclophosphamide plus G-CSF as a mobilization strategy. All consecutive patients with complete set of data (and who underwent apheresis) treated between 2009 and 2013 with G-CSF and plerixafor and all consecutive patients with complete data (and who underwent apheresis) treated between 2009 and 2013 with G-CSF and cyclophosphamide will be included. All data that will be analyzed will be extracted from the selected IFM institutions which are located in France.
Interventions
None listed
Sponsors
Intergroupe Francophone du Myelome
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Hematology patients diagnosed with Multiple Myeloma who are candidates for autologous hematopoietic stem cell transplantation (ASCT) upfront. * Age \> 18 years * Undergone prior successful peripheral blood stem cell mobilization with Cyclophosphamid or Plerixafor
Exclusion criteria
* Age \< 18 years; * Primary diagnosis other than Multiple Myeloma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total cost of stem cell mobilization procedure (including remobilisation if applicable) | 2009-2013 |
Secondary
| Measure | Time frame |
|---|---|
| Number of visits for administration of mobilizing agents | 2009-2013 |
| Duration (days) of administration of mobilizing agents | 2009-2013 |
| Agents used as mobilizing agents | 2009-2013 |
| Attainment of CD34+ target (yes, no) (min 2.106 cells/kg, ideal >4.106cells/kg) | 2009-2013 |
| Number of days needed to meet CD34+ target level (min 2.106 cells/kg, ideal >4.106cells/kg) | 2009-2013 |
Countries
France
Outcome results
None listed