Neural Bases of Multiple Forms of Self-regulatory Control in Bulimia Nervosa

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02997475

Acronym

SRBN

Enrollment

Registered

2016-12-20

Start date

2016-06-30

Completion date

2022-07-31

Last updated

2023-01-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bulimia Nervosa

Keywords

Bulimia Nervosa, Bulimia, fMRI, Emotion Regulation, Response Inhibition

Brief summary

The purpose of this study is to investigate areas of the brain responsible for self-regulation in adult women who have never had an eating disorder with women who have bulimia nervosa. More specifically, investigators are interested in changes in brain activation (e.g., changes in blood flow and oxygen use) when inhibiting responses and regulating emotions. Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

General Inclusion Criteria: * Female * Right-handed * Between the ages of 18 and 35 years \*For Women with Bulimia Nervosa: * Binge eating (i.e., eating a large amount of food while experiencing a sense of loss of control) * Purging via self-induced vomiting (other methods may also be endorsed) General

Exclusion criteria

* Current significant medical illness or condition (e.g., diabetes, thyroid disease) * Pregnancy, planned pregnancy, or lactation during the study period * Non-removable metallic objects in the body

Design outcomes

Primary

Measure	Time frame	Description
Self-Regulatory Control	Day 2 (fMRI Scan)	Functional Magnetic Resonance Imaging will be used to assess brain activation associated with motor inhibitory control and affect regulation in women with bulimia nervosa (BN)

Secondary

Measure	Time frame	Description
Goal-Directed Action Control	Day 1	An computerized instrumental learning task will be used to assess performance of women with and without bulimia nervosa.
Eating Disorder Relevance	Day 0	The Eating Disorder Examination (EDE) will be conducted to assess relative associations of motor, affective, and goal-directed action control with bulimia nervosa severity.

Countries

United States

Outcome results