Postoperative Pain Management
Conditions
Keywords
intravenous lidocaine, postoperative pain management
Brief summary
This study was to evaluate the effect of intraoperative intravenous lidocaine on postoperative pain management after laparoscopic cholecystectomy. Half of patients will receive intravenous lidocaine during procedure, the rest half of patients will receive regular anesthesia care and placebo treatment.
Detailed description
Postoperative pain and ileus are primary reasons for delayed patient recovery and longer hospital stays after abdominal surgery. Opioids have been widely used to treat pain in this patient population. However, opioid administration can exacerbate postoperative ileus and further delay patient recovery. Multimodal approaches and adjunctive therapies are therefore recommended for pain control after abdominal surgery to reduce opioid consumption and opioid-related adverse effects. Studies have reported that systemically administered lidocaine has analgesic, anti-inflammatory, and anti-hyperalgesic effects. Several clinical trials have been published that evaluated systemically administered lidocaine for postoperative pain management and recovery after surgery. However, the evidence for beneficial effects of systemic lidocaine for postoperative recovery remains controversial. Therefore, the investigators performed this study to evaluate the efficacy of systemic administration of lidocaine for postoperative analgesia and gastrointestinal recovery after laparoscopic cholecystectomy. The investigators primary hypothesis is that systemic lidocaine administration reduces pain intensity following surgery.
Interventions
DRUGLidocaine
lidocaine infusion during surgery
DRUGSaline Placebo
saline infusion at same rate as intervention group during surgery
Sponsors
Beijing Tongren Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologist (ASA) status I-II adult patients undergoing elective laparoscopic cholecystectomy.
Exclusion criteria
* Open surgery; * Patients allergic to lidocaine or other local anesthetics; * Drug abuser.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postoperative pain score | 6 hours after surgery | visual analogue score (1-10) |
| total postoperative opioid consumption | 48 hours after surgery | postoperative fentanyl consumption |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| incidence of postoperative complication | 48 hours after surgery | opioid-related side effects, such as nausea and vomiting, and the incidence of adverse effects associated with systemic administration of lidocaine. |
Countries
China
Outcome results
None listed