Urinary Tract Infections
Conditions
Brief summary
This is a retrospective chart review using Electronic Privacy Identification Center (EPIC) database to determine if the addition of cranberry juice capsules to our discharge medication regimen for patients discharged home with an indwelling urinary catheter following pelvic floor gynecology surgery reduced the incidence of UTI.
Detailed description
The incidence of urinary tract infection (UTI) in women undergoing pelvic floor gynecologic surgery is high, ranging from 10-64%. A recent randomized trial showed that cranberry juice capsules significantly reduced the incidence of UTI in patients undergoing elective gynecologic surgery (19% vs 38%; odds ratio 0.38 with confidence interval 0.19-0.79). Cranberry juice capsules were incorporated into the standard practice of Cincinnati Urogynecology Associates, TriHealth Inc in mid-March 2016. Currently, all patients who undergo pelvic floor gynecologic surgery and are discharged from the hospital with an indwelling urinary catheter postoperatively are prescribed cranberry juice capsules to reduce the risk of UTI. The purpose of this study is to determine if the addition of cranberry juice capsules to the discharge medication regimen for patients discharged home with an indwelling urinary catheter following pelvic floor gynecology surgery significantly reduced the incidence of UTI, compared to a separate cohort that did not have cranberry prescribed.
Interventions
None listed
Sponsors
TriHealth Inc.
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Underwent pelvic floor gynecologic surgery between April 2015 and September 2015, and April 2016 and September 2016 * Required indwelling urinary catheter use upon discharge from the hospital.
Exclusion criteria
* Intraoperative bladder injury, fistula repair, urethral diverticulectomy, or any other need for prolonged catheterization * Complications in the 2 weeks following surgery requiring reoperation and subsequent catheter use * Allergy to cranberry or its components * Failure to present for both the two-week and six-week postoperative office visit
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Incidence of UTI | within 6 weeks postoperative |
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Cranberry Group Patients underwent pelvic floor gynecologic surgery performed by a physician at Cincinnati Urogynecology Associates, TriHealth Inc between April 2016 and September 2016 and discharged home with an indwelling urinary catheter following the surgery. This group of people had cranberry juice capsules prescribed. | 96 |
| No Cranberry Group Patients underwent pelvic floor gynecologic surgery performed by a physician at Cincinnati Urogynecology Associates, TriHealth Inc between April 2015 and September 2015. This group of people did not have cranberry juice capsules prescribed. | 71 |
| Total | 167 |
Baseline characteristics
| Characteristic | Cranberry Group | No Cranberry Group | Total |
|---|---|---|---|
| Age, Continuous | 60.28 years STANDARD_DEVIATION 14.1 | 59.62 years STANDARD_DEVIATION 15.29 | 60.00 years STANDARD_DEVIATION 14.57 |
| Race/Ethnicity, Customized African American | 6 Participants | 4 Participants | 10 Participants |
| Race/Ethnicity, Customized Asian | 1 Participants | 1 Participants | 2 Participants |
| Race/Ethnicity, Customized Hispanic | 3 Participants | 0 Participants | 3 Participants |
| Race/Ethnicity, Customized Other | 0 Participants | 2 Participants | 2 Participants |
| Race/Ethnicity, Customized White | 86 Participants | 64 Participants | 150 Participants |
| Region of Enrollment United States | 96 participants | 71 participants | 167 participants |
| Sex: Female, Male Female | 96 Participants | 71 Participants | 167 Participants |
| Sex: Female, Male Male | 0 Participants | 0 Participants | 0 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 96 | 0 / 71 |
| other Total, other adverse events | 0 / 96 | 0 / 71 |
| serious Total, serious adverse events | 0 / 96 | 0 / 71 |
Outcome results
Primary
The Incidence of UTI
Time frame: within 6 weeks postoperative
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| Cranberry Group | The Incidence of UTI | 66 Participants |
| No Cranberry Group | The Incidence of UTI | 54 Participants |
p-value: 0.299Chi-squared