Interval Training Study in Psoriatic Arthritis

Conditions

Psoriatic Arthritis

Keywords

Exercise Therapy

Brief summary

Psoriatic arthritis is a chronical inflammatory disease characterized by pain and reduced physical function. Patients have a higher risk of cardiovascular disease and a higher body mass index. A pilot study in patients with rheumatoid arthritis has shown positive effect on inflammation after 12 weeks of high-intensity interval training. The primary aim of this study is to determine whether high-intensity interval training affects the disease activity in psoriatic arthritis. This intervention is believed to result in benefits in terms of inflammation, body composition and risk factors for cardiovascular disease.

Ruth Stoklund Thomsen, Tom Ivar Lund Nilsen, Glenn Haugeberg, Beathe Sitter, Arthur Kavanaugh et al. (7 authors)

BMC Musculoskeletal Disorders2023-09-199 citations

10.1186/s12891-023-06871-3

Effect of high-intensity interval training on cardiovascular disease risk factors and body composition in psoriatic arthritis: a randomised controlled trial

Ruth Stoklund Thomsen, Tom Ivar Lund Nilsen, Glenn Haugeberg, Anja Bye, Arthur Kavanaugh et al. (6 authors)

RMD Open2018-10-0132 citations

10.1136/rmdopen-2018-000729

Quantifying bone marrow inflammatory edema in the spine and sacroiliac joints with thresholding.

Chronaiou I, Thomsen RS, Huuse EM, Euceda LR, Pedersen SJ, Hoff M, Sitter B.

2017-11-286 citations

10.1186/s12891-017-1861-1

Interventions

BEHAVIORALinterval training

4x4 high intensity interval training

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

No

Inclusion criteria

* fulfilling the CASPAR criteria of psoriatic arthritis * ability to exercise.

Exclusion criteria

* Inability to exercise * very high disease Activity * unstable ischemic cardiovascular disease * severe pulmonary disease * pregnancy * breastfeeding * drug- and alcohol addictions

Design outcomes

Primary

Measure	Time frame	Description
Maximal oxygen uptake (VO2 max)	Baseline, 3 months (right after intervention), 9 months	The VO2 max is measured as a change between timepoints
Patient global assesment (PGA)	Baseline, 3 months (right after intervention), 9 months	PGA is measured as a change between timepoints. PGA is registered by the patient on a visual analog scale.

Secondary

Measure	Time frame	Description
Total lean mass	Baseline, 3 months (right after intervention), 9 months	Total lean mass is measured as a change between timepoints and is measured by dual energy x-ray absorptiometry (DXA).
Total body fat	Baseline, 3 months (right after intervention), 9 months	Total body fat is measured as a change between timepoints and is measured by dual energy x-ray absorptiometry (DXA).

Outcome results

None listed