Evaluation of the Axonemal Dynein Heavy Chain 5 and Creatine Kinase Concentration in Cervical Fluid for Early Detection of the Ectopic Pregnancy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02995356

Enrollment

Registered

2016-12-16

Start date

2016-09-30

Completion date

2018-11-30

Last updated

2019-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ectopic Pregnancy

Keywords

Ectopic pregnancy, Axonemal Dynein Heavy Chain 5, Creatine Kinase, Cervical fluid

Brief summary

Patients who have doubt for ectopic pregnancy will be enrolled for our study. These patients will be determined with using irregular increased human chorionic gonadotropin (beta-HCG) results and no embryo reported ultrasonography results. Plasma and cervical fluid samples will be taken from these patients and axonemal dynein heavy chain 5 and creatine kinase levels of samples will be compared between patients who have doubt for ectopic pregnancy and patients who have intrauterine pregnancy. Concentration of these proteins in samples will be evaluated. If any difference will be found between groups in favour of ectopic pregnancy, these results might be interpreted as these proteins useful for early detecting of the ectopic pregnancy.

Interventions

OTHERCollecting cervical liquid and sera samples

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Doubted ectopic pregnancy * Without any finding about intrauterine pregnancy in ultrasonography results * Without any vaginal bleeding * Having irregular pregnancy test results * Beta-HCG results should be at least upper than 100 milli-International unit (mIU/ml) * Having fist trimester pregnancy for intrauterine pregnancy group * Without any emergency findings

Exclusion criteria

* Doubted incomplete abortion * Having vaginal bleeding * Having ultrasound results which include intrauterine embryo report * Having lower than 100 mIU/ml beta-HCG results * Without fetal heart rate in intrauterine pregnancy group * Having older than fist trimester pregnancy for intrauterine pregnancy group * Having emergency findings

Design outcomes

Primary

Measure	Time frame
Concentration of Axonemal Dynein Heavy Chain 5	1 year
Concentration of creatine kinase	1 year

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 16, 2026