Allergic Reaction to Nickel
Conditions
Keywords
Microneedles, Biocompatibility, Allergy, Metal, Nickel, Contact dermatitis
Brief summary
Hypodermic needles are conventionally used to deliver drugs and vaccines into the muscle of humans and animals. Side effects of these needle injections are pain, bleeding, and anxiety in patients. An alternative drug and vaccine delivery method is the use of hollow microneedles, which are sub-millimeter needle-like structures. Microneedles are pain- and bleeding-free, as they do not reach the nerve-endings and blood capillaries in the skin. As a result, they are better received by patients and do not induce needle anxiety. As the investigators' microneedles are made of gold- or silver-coated, as well as uncoated nickel, the purpose of this study is to observe their biocompatibility and inertness.
Interventions
DEVICEGold- or silver-coated, or uncoated nickel microneedles
The stratum corneum of the participants will be breached with the gold- and silver-coated, or uncoated nickel microneedles.
Sponsors
Canadian Institutes of Health Research (CIHR)
University of British Columbia
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Proven nickel allergy
Exclusion criteria
* Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Skin reaction as measured by a contact dermatitis classification system | 7 days | Allergic patch-test based grading will be done according to the Wilkinson DS et al 1970 reference. |
Countries
Canada
Outcome results
None listed