Preterm Birth
Conditions
Keywords
preterm birth, corticosteroids, inflammatory parameters, betamethasone, leukocytes
Brief summary
It is the aim of this study to detect the effect of Betamethasone on the maternal inflammatory parameters C-reactive protein (CRP) and leukocytes of a pregnant woman under threat of preterm delivery, for example because of a cervical infection.
Detailed description
BACKGROUND Cortisone influences the maternal number of leukocytes and CRP of a pregnant woman. Because of that, it is difficult to know if the medical treatment of an infection was successful and accordingly if the diagnosis was justified. METHODS In this study, the blood results of 75 pregnant women under threat of preterm delivery (week of gestation 23+0 to 34+6), treated with Betamethasone will be analysed. 65 pregnant women without complications serve as control group.
Interventions
None listed
Sponsors
Medical University of Vienna
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* week of gestation 23+0 until 34+6
Exclusion criteria
* infectious diseases f.e. hepatitis B or C, HIV * diseases of the thyroid gland 75 Patients facing preterm labour 65 Patients acting as a control group, without preterm labor
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CRP | 48h | The CRP values in mg/dL before and 48h after the first Betamethasone application |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Leucocytes | 48h | The Leucocyte values in G/L before and 48h after the first Betamethasone application |
Other
| Measure | Time frame | Description |
|---|---|---|
| Height | single point in the time frame between week of gestation 23+0 - 34+6, no fixed day | Size in meters (m) is taken from the medical record to calculate the BMI in both groups (case and control) |
| CRP Control Group | single point in the time frame between week of gestation 23+0 - 34+6, no fixed day | CRP values in mg/dL of patients belonging to the control group |
| Leucocytes Control Group | single point in the time frame between week of gestation 23+0 - 34+6, no fixed day | Leucocyte values in G/L of patients belonging to the control group |
| Body Mass Index (BMI) | single point in the time frame between week of gestation 23+0 - 34+6, no fixed day | Body Mass Index (BMI) in kg/m\^2 is calculated to test for influence on inflammatory parameters in both groups (case and control) |
| Patients with Diabetes | single point in the time frame between week of gestation 23+0 - 34+6, no fixed day | information about the patients diabetes status (diabetes yes or no) is taken from the medical record to test for influence on inflammatory parameters in both groups (case and control) |
| Smoking Habits | single point in the time frame between week of gestation 23+0 - 34+6, no fixed day | information about the patients smoking status (smoking yes or no) is taken from the medical record to test for influence on inflammatory parameters in both groups (case and control) |
| Patients with Allergies | single point in the time frame between week of gestation 23+0 - 34+6, no fixed day | information about the patients allergie status (allergies yes or no) is taken from the medical record to test for influence on inflammatory parameters in both groups (case and control) |
| Weight | single point in the time frame between week of gestation 23+0 - 34+6, no fixed day | Weight in kilogram (kg) is taken from the medical record to calculate the BMI in both groups (case and control) |
Countries
Austria
Outcome results
None listed