Anesthesia, Spinal
Conditions
Brief summary
Under the hypothesis that dexmedetomidine sedation would result in less upper airway obstruction, we evaluated the occurrence of upper airway collapse or the requirement of airway intervention in patients with obstructive sleep apnea during dexmedetomidine or propofol sedation.
Interventions
DRUGDexmedetomidine
As a loading dose, 0.5 μg/kg dexmedetomidine was administered over 10 min, which was then administered continuously at a dose of 0.2-0.8 μg/kg/h. Sedation was maintained at modified observer's assessment of alertness/sedation scale 3
DRUGPropofol
Propofol was infused continuously via a target-controlled infusion device, and the effect-site concentration was maintained with a range of 0.5-2.0 μg/ml. Sedation was maintained at modified observer's assessment of alertness/sedation scale 3
Sponsors
Seoul National University Bundang Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Surgery under spinal anesthesia * Intraoperative sedation * American Society of Anesthesiology physical status 1 or 2 * Apnea/hypopnea index 5-14/h in Watch-PAT 200 analysis
Exclusion criteria
* Anatomical defects on upper respiratory tract * Psychotic disorder * Drug addition * Alcohol addition * body mass index ≥ 35 kg/m2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The occurrence of upper airway obstruction | During the sedation period, an average of 3 hours. | When end-tidal carbon dioxide was not detected in spite of the respiratory effort during the sedation period, the case will be regarded as the occurrence of upper airway obstruction. |
Countries
South Korea
Outcome results
None listed