Low Ovarian Reserve
Conditions
Brief summary
Assisted reproduction patients candidates to an IVF/ICSI cycle with low follicular reserve: after at least one cycle of stimulation obtaining 0-4 oocytes. Improve the follicular response in patients with low response, increasing the number of follicles in subsequent cycles to treatment with growth factors.
Interventions
DRUGGrowth Factors
one dose 3-6 mL of PRP obtained by PRGF Endoret
Sponsors
IVI Bilbao
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 42 Years
Healthy volunteers
No
Inclusion criteria
1. Patients must give written consent. 2. To be a healthy woman acting voluntarily, aged 18 to 42 years (both inclusive) at the time of study selection time of selection for the study. 3. Have a BMI ≥ 18 kg/m2 and ≤ 35 kg/m2 4. Patients with low ovarian reserve (AMH \<1.1 ng/mL) according to the Bologna criteria. 5. Patients who are going to undergo IVF/ICSI cycle with low follicular response: who after a previous cycle of stimulation have obtained 0-3 or more follicular 0-3 oocytes have been obtained after a previous stimulation cycle; or if 0-3 oocytes are expected to be obtained at the present time (less than 4 follicles). oocytes (less than 4 follicles in the basal ultrasound). 6. To have recent analytical results (haemogram, biochemistry and coagulation); at least 11 months prior to inclusion in the study and a serology, according to clinical practice. Translated with www.DeepL.com/Translator (free version)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of follicles recruited after instability of ovarian growth factors | two months; Time included in two protocols of ovarian stimulation | o demonstrate an increase of at least 20% in the number of MII oocytes in a cycle after IVF/ICSI treatment with PRGF®-Endoret® compared to previous cycles in low IVF/ICSI patients. IVF/ICSI treatment with PRGF®-Endoret® with respect to previous cycles in low responders. responders |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rates of pregnancy rates | three months after embryo transfer after treatment of growth factors | Increase pregnancy rates and decrease the number of cycles of accumulation of oocytes. |
Countries
Spain
Outcome results
None listed