Postoperative Cognitive Dysfunction
Conditions
Keywords
non-cardiac surgery, Postoperative Cognitive Dysfunction
Brief summary
To study on the Postoperative Cognitive Dysfunction: Correlations With Olfactory Dysfunction and Related Gene Changes.To explore whether the olfactory dysfunction could be used as a predictor of POCD and to provide reference for POCD prevention, early detection and timely diagnosis and treatment.
Interventions
None listed
Sponsors
Han Yuan
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Between 60 to 85 years old; * Undergoing non-cardiac and non-neurological surgery under general anesthesia; * Expected hospital stay ≥5 days; * American Society of Anesthesiologists class I or II.
Exclusion criteria
* Mental or neurodegenerative diseases; * History of severe trauma or surgery within one year; * History of nasal or sinus illness or surgery; * Cold or influenza within 3 weeks; * Significant history of organ dysfunction; * Previous neuropsychological testing; * Difficulty to perform tests (including severe visual or auditory disorders); * Mini-Mental State Examination (MMSE) \<24 points, \<20 points if the participant only attended elementary school, or \<17 points if the participant did not go to school.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the neuropsychological test battery to measure cognitive function | 1 day before surgery(baseline) |
| olfaction test to measure the sense of smell | 1 day before surgery(baseline) |
| the neuropsychological tests to measure cognitive function | within 5 to 10 days (average of 7 days) after surgery |
Countries
China
Outcome results
None listed